SARS-Coronavirus Open Reading Frame-3a drives multimodal necrotic cell death.

Cell Death Dis · 2018 · PMC6125346 · PMID 30185776

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may be significantno p-value reported

The activation of TFEB may be significant as TFEB directly transcriptionally activates proinflammatory cytokines in macrophages (including IL-1β, IL-2, and IL-27) and promotes a macrophage proinflammatory state 51 , 52 .

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