EVI1 carboxy-terminal phosphorylation is ATM-mediated and sustains transcriptional modulation and self-renewal via enhanced CtBP1 association.

However, in the presence of genotoxic stress mediated by H 2 O 2 or radiation, we observed a highly significant increase in spatial association of EVI1-WT with CtBP1 of 22.1% ±- 4.4 SEM with H 2 O 2 ( n = 4, P < 0.01), and of 22.7% ± 2.4 SEM after radiation ( P < 0.001) (Figure 6A , upper two panels and 6B).

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