Integrating Rio1 activities discloses its nutrient-activated network in Saccharomyces cerevisiae.

The overlaps between Rio1 and the heat, osmotic, and nutritional regulons remained highly significant ( P -values = 1.7E-11, 3.2E-23 and 2.9E-12, respectively), indicating a shared response to extracellular cues that covers but also extends way beyond regulating ribosome production and activity.

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