op-has-supplement no pmc-prop-pdf-only no pmc-prop-suppress-copyright no pmc-prop-is-real-version no pmc-prop-is-scanned-article no pmc-prop-preprint no pmc-prop-in-epmc yes pmc-license-ref CC BY-NC-SA Introduction Acute ischemic stroke (AIS) has a recurrence rate of 13% by 1 year that accounts for an increasing trend toward elevated global burden of stroke.[ 1 2 ] Around a quarter of AIS patients notice stroke symptoms on awakening (wake-up stroke [WUS]),[ 3 4 ] and no clear time of symptom onset could be ascertained in these cases.
1
—
—