The microanatomy of the chondron, specifically its likelihood for promoting restricted diffusion of e.g., K + and metabolites is likely to be significant factors regulating the chondrocyte “microenvironment.” Within this functional space emerging knowledge of glucose transport (and hence cellular energetics), as well as paracrine and inflammatory factor profiles, will need to be further defined and accounted for (c.f.
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The Resting Potential and K<sup>+</sup> Currents in Primary Human Articular Chondrocytes.
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