Particular CSF sphingolipid patterns identify iNPH and AD patients.

Sci Rep · 2018 · PMC6133966 · PMID 30206302

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a decreasing trendno p-value reported

4 ) revealed a decreasing trend, although not statistically significant, in AD patients compared to iNPH, whereas, Anti-Ceramidase antibody (anti-ASAH2) was tested on the same sub-pools but ceramidase was, in our hands, undetectable in CSF samples.

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an increasing trendno p-value reported

LC-MS identified an increasing trend of Cer C24:0 and of a set of SMs in patients with AD, a significant decrease of sphingosine-1-phosphate (S1P) (t-test p-value 0.0325) and an increase of glucosylceramide (GlcCer) C24:0 (p-value 0.0037) in AD compared to iNPH patients.

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