Identification of a novel site of interaction between ataxin-3 and the amyloid aggregation inhibitor polyglutamine binding peptide 1.

26 However, as the thioredoxin-polyQ fusion protein is a non-disease protein, it has been suggested that this finding may not be significant to polyQ pathology. 27 Other studies have also suggested that QBP1 interacts with polyQ protein monomers and prevents their pre-oligomerisation β-sheet conformational switch. 28 Previous work has demonstrated that QBP1 inhibits the polyQ-dependent stage of ataxin-3 aggregation, while having no effe

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