Permutation analysis showed that the change in metabolic fluxes predicted from gene expression changes during Parkinson’s disease was highly significant in the metabolic network: taken over all studies which showed substantial variation, all reaction rates were significantly affected during Parkinson’s disease, except CO 2 production and glutamine synthetase ( S4 Table ).
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Computational prediction of changes in brain metabolic fluxes during Parkinson's disease from mRNA expression.
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