Barely Significant
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Combined detection of IL-6 and IL-8 is beneficial to the diagnosis of early stage esophageal squamous cell cancer: a preliminary study based on the screening of serum markers using protein chips.

Onco Targets Ther · 2018 · PMC6140751 · PMID 30254470

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an increasing trendno p-value reported
51 Wang et al 52 detected the expression of MMP-8 protein in 15 cases of ESCC and paired distant cancer tissues, showing an increasing trend from T 1 to T 4 stage and no significant difference between different lymph node metastasis groups.

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