Modulation of Microglial Activation by Adenosine A2a Receptor in Animal Models of Perinatal Brain Injury.

Front Neurol · 2018 · PMC6141747 · PMID 30254599

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A2aR modulation is involved in the regulation of M1-M2 microglia phenotype in excitotoxic-induced inflammation In our in vitro model of excitotoxic activation of primary microglial cells, highly significant increase in gene expressions of IL1β, IL6, iNOS, TNFα, and IL10 were was observed in response to 300 μM IBO exposure for 6 h (Figure 8 ).

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