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The Pain Divide: a cross-sectional analysis of chronic pain prevalence, pain intensity and opioid utilisation in England.

BMJ Open · 2018 · PMC6144392 · PMID 30206064

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an increasing trendno p-value reported
For example, a recent study by Mordecai et al showed that, at a clinical commissioning group level, over a 4-year period, there was an increasing trend of opioid prescribing—with more opioid analgesics prescribed in the North of England, compared with the South. 26 Our work builds on these findings, and shows that the increased trend of opioid prescribing is associated with an increase in health need (pain), rather than an ‘inappropriate’ prescribing trend of opioid analgesics.

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