Amyloid positron emission tomography and cerebrospinal fluid results from a crenezumab anti-amyloid-beta antibody double-blind, placebo-controlled, randomized phase II study in mild-to-moderate Alzheimer's disease (BLAZE).

There was a nonsignificant trend toward treatment difference observed in the high-dose IV cohort of 0.024 (95% CI –0.011 to 0.060; unadjusted p = 0.169) for SUVR BAI-WM , representing a 30% reduction in amyloid accumulation relative to placebo (Fig. 2e ).

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