Inosine Triphosphate Pyrophosphatase Dephosphorylates Ribavirin Triphosphate and Reduced Enzymatic Activity Potentiates Mutagenesis in Hepatitis C Virus.

Among 25 HCV genotype 1-infected, noncirrhotic patients treated with the interferon- and ribavirin-free combination of daclatasvir, asunaprevir, and beclabuvir for 12 weeks in the UNITY-1 trial ( 56 ) and having resistance-associated substitutions (RASs; also known as resistance-associated variants or RAVs) directed against the HCV protein NS5A at baseline prior to therapy, a nonsignificant trend toward improved outcome was observed in the seven patients having genetic variants encoding reduced ITPase activity ( Fig. 7 ).

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