S7 , tubulogenesis was not arrested in Vps34 Δ/Δ kidney (comparable proportion of immature over mature patterns), and mislocalization of NaPi-IIa at P14 proved highly significant.
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Vps34/PI3KC3 deletion in kidney proximal tubules impairs apical trafficking and blocks autophagic flux, causing a Fanconi-like syndrome and renal insufficiency.
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