Therapeutic implications of how TNF links apolipoprotein E, phosphorylated tau, α-synuclein, amyloid-β and insulin resistance in neurodegenerative diseases.

All three of these reports are extremely significant events for researchers concerned with finding practical treatments for AD and PD, since they demonstrate, for the first time, that chronically reducing just one parameter, cerebral TNF levels, can alter the frequency of onset of these two important neurodegenerative states.

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More recently, systemic anti‐TNF therapy of inflammatory bowel disease has also been associated with a highly significant 78% reduction in the onset of PD (Peter et al ., 2018 ).

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