Genome-Wide DNA Methylation Analysis during Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells.

Stem Cells Int · 2018 · PMC6151374 · PMID 30275838

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It is reported that specific and reproducible epigenetic changes were acquired by MSCs during ex vivo culture, and DNA methylation patterns had highly significant differences only at specific CpG islands associated with promoter regions, such as in homeobox genes and genes involved in cell differentiation [ 22 , 23 ].

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