Intramolecular Hydrogen Bonding Involving Organic Fluorine: NMR Investigations Corroborated by DFT-Based Theoretical Calculations.

Consequent to the binding nature of fluorinated molecules with enzyme active sites, intermolecular hydrogen bonds of the type X-H···F-C (X = O, N) are highly significant, especially in bio-inorganic and medicinal chemistry [ 80 , 81 , 82 , 83 , 84 ].

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