Tracing a protein's folding pathway over evolutionary time using ancestral sequence reconstruction and hydrogen exchange.

Elife · 2018 · PMC6158009 · PMID 30204082

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a notable trendno p-value reported

An analysis of the intrinsic helical propensity of each region using the algorithm AGADIR ( Muñoz and Serrano, 1994 ) shows a notable trend in helicity that correlates with the early folding events ( Figure 4 ).

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