highly significantp ≤ 0.001
The mediator analysis did not support the hypothesis of a mediating effect of CRP on the association between RMR and HOMA-IR in both unadjusted and adjusted analyses since HOMA-IR remained highly significant (adjusted: ß = 28.4 ± 7.5, p ≤ 0.001) after inclusion of CRP (Table 3 ).