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Painless lump over the forehead which turned painful: an unusual presentation of hepatocellular carcinoma.

BJR Case Rep · 2015 · PMC6159124 · PMID 30363169

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an increasing trendno p-value reported
They noted an increasing trend towards the reporting of skull metastases from HCC from the year 1990 onwards.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.