Diabetes, plasma glucose and incidence of colorectal cancer in Chinese adults: a prospective study of 0.5 million people.

15 16 A prospective cohort study in the USA reported a decreasing trend in CRC risk with longer duration of diabetes, with HRs of 2.36 (0.96 to 5.79), 1.71 (0.63 to 4.61) and 1.01 (0.48 to 3.12) for 4–8, 8–12 and ≥12 years of diabetes. 15 Similarly, a record linkage study in Israel reported a decreasing trend between duration of diabetes and CRC risk, although the longest duration was 11 years. 16 The high risk of CRC in the first few years following diagnosis of diabetes might be due to surveillance bias and reverse causality, while the relatively low risk might reflect hypoinsulinaemia and glycaemic control over the course of diabetes.

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