Safety and pharmacokinetics of single, dual, and triple antiretroviral drug formulations delivered by pod-intravaginal rings designed for HIV-1 prevention: A Phase I trial.

PLoS Med · 2018 · PMC6161852 · PMID 30265679

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may be significantno p-value reported

The observation may be significant since the VT bioavailability in sheep of the TDF prodrug is nearly 100 times higher than for parent TFV [ 40 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.