Cognitive Impairment in Chronic Obstructive Pulmonary Disease (COPD): Possible Utility of Marine Bioactive Compounds.

Gracilin(s), with chemical formula C 15 H 20 O 3 ( Figure 12 ), a family of diterpenoid compounds, isolated from the sponge Spongionella , in 3xTg-AD mice (triple-transgenic mouse model of AD, the only model that exhibits both Aand pathology characteristic of the human form), after chronicintraperitoneal treatments, in preliminary behavioral test, points to a positive trend on learning and spatial memory of treated mice.

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Nevertheless, according to the US Burden of Disease Collaborators, in 2016 COPD was the third cause of death in the United States, with an increasing trend in comparison with 2010 [ 96 ].

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