A borderline significant association with the Reactome database pathways was explained because in the database, one pair of paralogous serine/threonine kinases ( YPK1 and YPK2 , overlapping in 31% of their enzyme expression changes) is associated with 42% of signaling pathways (Wilcoxon rank-sum test, p = 0.03; Figure S9 ).
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Machine Learning Predicts the Yeast Metabolome from the Quantitative Proteome of Kinase Knockouts.
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