highly significantP <0.001
37 Yaman Agaoglu et al found that the differences in miRNA plasma levels between the healthy controls and the patients were highly significant for the miR-21 ( P <0.001) and -221 ( P <0.001) but not for the miR-141( P =0.23). 38 An analysis of 742 miRNAs using plasma-derived circulating microvesicles (cMVs) from 78 PCa patients and 28 healthy individuals identified differentially expressed miRNAs that included upregulation of miR-107, -130b, -141, -2110, -301a, -326, -331-3p, -432, -484, -574-3p, and -625 and downregulation of miR-181a-2.