FTO genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials.

Change in body mass index for each copy of the FTO minor allele was significant in participants aged 50 or more years (β −0.23 (95% confidence interval −0.44 to −0.22); I 2 0 (95% confidence interval 0 to 75); P=0.03), but not in participants aged less than 50 years (β −0.04 (−0.26 to 0.18); I 2 0 (0 to 75); P=0.75); however, the corresponding moderation test failed to attain significance (P=0.21).

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