Simvastatin Protects Cardiomyocytes Against Endotoxin-induced Apoptosis and Up-regulates Survivin/NF-κB/p65 Expression.

The myocardial samples from the Simvastatin 40 group had importantly decreased incidence of cleaved caspase-3 positive muscle cells than those from the Simvastatin 20 group (20.6 ± 3.1% and 32.1 ± 5.8%, p < 0.05, respectively), and highly significant compared to the LPS group ( p < 0.01) (Fig. 3c–e ).

also in 132,142 other papers

These data have provided important new insights into understanding of simvastatin-induced anti-apoptotic and pro-survival actions in experimental sepsis and related organ injury stress, that may be significant basis for the clinical use of statins for SIMD, but this warrants further clinical investigation.

also in 13,097 other papers