Phenotypically distinct female castes in honey bees are defined by alternative chromatin states during larval development.

In agreement with our previous observations at the TET locus, genes that are significantly more expressed in 96hW show highly significant enrichment for 96hW intronic H3K27ac (1.75-fold enrichment; P -value <0.001), whereas those genes significantly more expressed in 96hQ are actually depleted for 96hQ intronic H3K27ac (2.06-fold depletion; P -value <0.001) ( Fig. 4 C).

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