Study on safety of laparoscopic total gastrectomy for clinical stage I gastric cancer: the protocol of the CLASS02-01 multicenter randomized controlled clinical trial.

Discussion Incidence of adenocarcinoma at the upper third of the stomach has increased over the past two decades in Western countries [ 14 ], and in Asian countries, such as Japan, Korea, and China, an increasing trend of proximal gastric cancer is also observed during the past years [ 15 ].

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