Enhanced ER proteostasis and temperature differentially impact the mutational tolerance of influenza hemagglutinin.

We note that understanding the evolutionary constraints of membrane and secretory proteins is critical, as they comprise highly significant therapeutic targets, including collagen ( DiChiara et al., 2016 ), G-protein coupled receptors ( Laschet et al., 2018 ), antibodies ( Wong et al., 2018 ), and viral membrane proteins ( Hurtley et al., 1989 ).

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