Proteomic phenotyping of metastatic melanoma reveals putative signatures of MEK inhibitor response and prognosis.

We further noted that the expression of ICAM-1 in de-differentiated tumors, defined as those with low PMEL expression (Supplementary Table 5 ), was a highly significant prognostic factor, where low ICAM-1 expression correlated with diminished MSS ( p < 0.0001, HR 25.1, 95% CI 6.0–104.6) with median survival of 8.4 months ( n = 10) for low ICAM-1 expression compared with an estimated 128.4 months ( n = 9) for high ICAM-1 expression (Fig. 5b ).

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