LABA/LAMA fixed-dose combinations in patients with COPD: a systematic review.

Int J Chron Obstruct Pulmon Dis · 2018 · PMC6174911 · PMID 30323582

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a numerical trendno p-value reported

9 Intriguingly, some of the LABA/LAMA FDCs showed a numerical trend in protecting against cardiovascular SAEs, whereas other combinations showed a signal in increasing the risk of cardiovascular SAEs. 9 The frequencies of SAEs and deaths in RCTs of LABA/LAMA FDCs are low.

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