Barely Significant
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Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control.

Nat Commun · 2018 · PMC6175862 · PMID 30297808

Europe PMCDOI
3
hedged sentences
0.0002
closest p · 0.0× alpha
0.0002
boldest claim

The sentences

highly significantp = 2.0 × 10 −4actually significant
1b ) revealed highly significant correlations of PC1 and PC2 with hepatic zones (PC1: r = 0.47, p = 2.0 × 10 −4 ; PC2: r = 0.86, p < 2.2 × 10 −16 , Supplementary Figure 3) indicating zonation as a major driver of variation between samples.

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a marginal trendno p-value reported
Our RNAseq data—in line with previous reports 24 —show that HNF4A expression shows only a marginal trend towards zonation (FDR PV_CV = 0.02, Log 2 FC PV_CV = –0.19).

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a weak trendno p-value reported
Like HNF4α , overall TCF7L2 (FDR PV_CV = 0.008, Log 2 FC PV_CV = 0.3) shows only a weak trend towards zonation.

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