Lower circulating angiotensin II levels are related to the severity of preeclampsia and its risk as disclosed by a specific bioassay.

At each gestational age studied, patients destined to develop preeclampsia had lower serum Ang II concentrations throughout gestation than HP women; these differences became markedly significant from week 24 onward ( P ≤.03 vs HP women). 6.3.

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As group, patients destined to develop pregnancy-induced hypertension, the pressor dose requirements were lower throughout gestation than HP women; these differences became highly significant at 23 to 26 weeks of gestation, and the difference between the groups became progressively widened thereafter.

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