Hierarchical groove discrimination by Class I and II aminoacyl-tRNA synthetases reveals a palimpsest of the operational RNA code in the tRNA acceptor-stem bases.

Nucleic Acids Res · 2018 · PMC6182185 · PMID 30016476

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Thus, the relative importance of base 2 in the tRNA acceptor stem is conspicuously consistent with both aaRS:tRNA pairing and the codon table! It is noteworthy that the logWorth values for base 2-related coefficients in Tale 2 are statistically highly significant despite the fact that the actual bases that those rules imply cannot be identified directly by inspection of Figure 1 .

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