It is noteworthy that, at a 5-year follow-up of phase-2 studies, the presence of CK was associated with a highly significant difference in median PFS in R/R CLL (31 months with CK compared to not reached in patients without CK and with 51 months in the entire cohort).
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Biological significance and prognostic/predictive impact of complex karyotype in chronic lymphocytic leukemia.
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