We previously showed that YAP was up-regulated in cSCC tissues and cell lines compared to normal controls, and its expression had an increasing trend from normal skin → precancerous lesions of actinic keratosis (AK) → carcinoma in situ (Bowen’s Disease) → well-differentiated cSCC → moderately and poorly differentiated cSCC 12 .
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Yes-associated protein promotes the abnormal proliferation of psoriatic keratinocytes via an amphiregulin dependent pathway.
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