MicroRNAs 143 and 150 in whole blood enable detection of T-cell immunoparalysis in sepsis.

We next crosschecked whether these three miRNAs actually indicate impairment of adaptive immune functions and found highly significant correlations between the expression levels of these three miRNAs and the T-cell specific markers of immunosuppression IL7R and ICOS (miR-143: r = − 0.95 and − 0.78, p < 0.0005, miR-150: r = 0.87 and 0.66, p < 0.005, miR-223: r = − 0,78 and − 0,64 p < 0.05), and, importantly, with SOFA-scores (miR-143: 0.65, miR-150: − 0.7, miR-223: 0.57, p < 0.01; see also Table 8 ) Thus, we suggest that determination of these miRNAs in T-cells provides a useful method to assess immunoparalysis in sepsis.

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