Genomic data integration systematically biases interactome mapping.

However, the same eight features resulted in highly significant increases in the proportion of previously known interactions ( Fig 5B ; all P ≤ 7.0 × 10 −26 , Fisher’s method, except P > 0.99 for gene fusion).

also in 93,232 other papers

We note as a caveat to this conclusion that, when we analyzed the subset of networks presented in Fig 3B that were generated with combinations of zero and three features, there was a marginally significant correlation between the number of external genomic features integrated and the proportion of interactions that were subsequently discovered (ρ = 0.17, P = 0.0055).

also in 17,465 other papers

This analysis confirmed the absence of a positive trend (ρ = –0.057, P = 0.13; S1 Fig ).

also in 7,469 other papers