Obese subcutaneous adipose tissue impairs human myogenesis, particularly in old skeletal muscle, via resistin-mediated activation of NFκB.

Furthermore, since SAT represents a much larger proportion of total adipose tissue mass than VAT 27 – 29 , its contribution to the systemic inflammatory burden to which skeletal muscle is exposed is likely to be significant.

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Given these findings, it is highly significant that depletion of resistin from obese SAT secretome reduced the anti-myogenic action of obese SAT conditioned media secretome.

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