Gene ontology analysis of the differentially expressed genes between cells treated with vehicle or M1 revealed a highly significant enrichment of genes related to IFN signalling (Fig. 4a ), indicating that activation of IFN pathway inhibits the replication of M1 virus and differing responsiveness of IFN may be responsible for the susceptibility of OV M1.
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DNA-PK inhibition synergizes with oncolytic virus M1 by inhibiting antiviral response and potentiating DNA damage.
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