Persistent mRNA and miRNA expression changes in irradiated baboons.

For these 21 miRNAs, all data from stage I and stage II were merged and analyzed together resulting in highly significant DEG that survived Bonferroni correction for multiple comparisons (p < 0.002 [0.05/21]) and ROC between 0.9–1.0 were calculated for most genes suggesting a complete or almost complete separation of gene expression relative to the pre-exposure reference (bold p-values, Supplement Table 2 , right part).

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Only CA2 showed a 2–5-fold up-regulation on days 7 and 28 during screening and validation with a borderline significance at day 7 (p = 0.07) and a high significance at day 28 (p < 0.0001, Table 2 , Fig. 2F ).

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