Highly significant top 10 miRNAs and all transcription factors were selected considering the degree-centrality of each node using NetworkAnalyzer [ 17 ]. 3 RESULTS NetworkAnalyst identified 17 and 546 differentially expressed (DE) genes ( P<0.05 ) in GSE26637 (G1) and GSE26637 (G2) respectively, indicating there exist large transcriptional differences between insulin sensitive-lean and insulin resistant-obese phenotypes, whereas other studies did not report any DE genes.
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A Network Biology Approach for Assessing the Role of Pathologic Adipose Tissues in Insulin Resistance Using Meta-analysis of Microarray Datasets.
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