Barely Significant
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Deciphering the rationale behind specific codon usage pattern in extremophiles.

Sci Rep · 2018 · PMC6195531 · PMID 30341344

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a decreasing trendno p-value reported
Preference of GC-rich and G/C-ending codons were observed in halophiles and barophiles whereas, a decreasing trend was reflected in psychrophiles and alkaliphiles.

also in 47,180 other papers

an increasing trendno p-value reported
The overall ranking predictions in T-M, P-M and T-P showed an increasing trend of CAA and decreasing trend of AGG from thermophiles to mesophiles to psychrophiles.

also in 63,971 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.