Ketogenic diets attenuate cyclooxygenase and lipoxygenase gene expression in multiple sclerosis.

We found a highly significant inverse correlation (p = 0.00004, r = −0.734) between these two clinical scores ( Table 2 + Supplemental Fig.

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In this inter-group comparison we also observed a statistic trend for declined expression of COX1 (adjusted difference 5890 ± 3238; 95% CI 843 to 12,623 COX1 mRNA copies/10 6 GAPDH mRNA copies) but the p-value of 0.08 suggested only borderline significance ( Table 3 + Supplemental Fig.

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We observed for all target genes a statistical trend for positive correlation with the EDSS index but owing to the relatively small n-numbers these correlations did not reach the level of significance (Supplemental: Table S2 + Fig.

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