Triazolo[4,5<i>-d</i>]pyrimidines as Validated General Control Nonderepressible 2 (GCN2) Protein Kinase Inhibitors Reduce Growth of Leukemia Cells.

Comput Struct Biotechnol J · 2018 · PMC6197744 · PMID 30364637

Europe PMC DOI

hedged sentence

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closest p

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boldest claim

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highly significantno p-value reported

The structural relationship between this template and the GCN2 kinase domain sequence was highly significant (pP = 10 –20.9 ) [ 38 ], and the template structure was of high resolution (1.8 Å) and contained a small molecule inhibitor bound to the active site, which are highly desirable features of a homology model template.

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