Intranasal niosomes of nefopam with improved bioavailability: preparation, optimization, and in-vivo evaluation.

Drug Des Devel Ther · 2018 · PMC6200089 · PMID 30410310

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highly significantno p-value reported

The increase in permeation of NF from all NF-loaded niosomes was found to be highly significant ( P -value ,0.01) compared with free drug using one-way ANOVA.

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