Expression-based analyses indicate a central role for hypoxia in driving tumor plasticity through microenvironment remodeling and chromosomal instability.

NPJ Syst Biol Appl · 2018 · PMC6200725 · PMID 30374409

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highly significantno p-value reported

For example, the highly significant mutations in genes like PIK3CA or KRAS are observed in ~30% of breast cancer patients.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.