Leptin gene polymorphism affects leptin level in childhood asthma.

World J Pediatr · 2018 · PMC6208747 · PMID 30203371

Europe PMC DOI

hedged sentences

0.0780

closest p · 1.6× alpha

0.0800

boldest claim

The sentences

marginal significanceP = 0.078so close (0.05 < p ≤ 0.1)

The patients also demonstrated significant differences in total IgE levels as compared to the controls (Table 1 ). Serum leptin and leptin receptor levels in atopic asthma We observed that serum leptin level was higher in asthmatic patients during exacerbation (13.81 ± 10.56 ng/mL) than in the control subjects (6.32 ± 5.20 ng/mL), but this difference showed marginal significance ( P = 0.078) (Fig. 1 a).

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marginally significantP = 0.08so close (0.05 < p ≤ 0.1)

Leptin and leptin receptor levels and genotypes We found that 5′-UTR LEP polymorphism (rs13228377) correlates with serum leptin levels, with AA genotype related to increased leptin level independent of asthma status, although the difference was marginally significant ( P = 0.08).

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