Under expression of the Sonic Hedgehog receptor, Patched1 (PTCH1), is associated with an increased risk of local recurrence in squamous cell carcinoma of the vulva arising on a background of Lichen Sclerosus.

PLoS One · 2018 · PMC6209322 · PMID 30379908

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may be significantno p-value reported

Our observation also suggests that Hh pathway dysregulation may be significant in the setting of LS, given that chronic inflammation can aberrantly active the Hh pathway [ 7 ].

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